DHEA-S
Dehydroepiandrosterone sulfate (DHEA-S) is the most abundant steroid hormone in the body, produced primarily by the adrenal glands. It serves as a precursor for both testosterone and estrogen. DHEA-S has a long half-life and stable levels throughout the day, making it a reliable marker of adrenal androgen production.
Why it matters: DHEA-S peaks in the mid-20s and declines steadily with age (adrenopause), dropping 80-90% by age 70-80. Low DHEA-S is associated with aging, cardiovascular disease, cognitive decline, reduced bone density, and decreased well-being. It is sometimes called the "anti-aging hormone" though evidence for supplementation benefits remains mixed.
May increase with:
May decrease with:
What is DHEA-S?
Dehydroepiandrosterone sulfate (DHEA-S) is the most abundant steroid hormone in the body, produced primarily by the adrenal glands. It serves as a precursor for both testosterone and estrogen. DHEA-S has a long half-life and stable levels throughout the day, making it a reliable marker of adrenal androgen production.
What might a high or low DHEA-S mean?
DHEA-S peaks in the mid-20s and declines steadily with age (adrenopause), dropping 80-90% by age 70-80. Low DHEA-S is associated with aging, cardiovascular disease, cognitive decline, reduced bone density, and decreased well-being. It is sometimes called the "anti-aging hormone" though evidence for supplementation benefits remains mixed.
What is the typical reference range for DHEA-S?
The general-population reference range shown here is 2.68 – 9.23 umol/L. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.
What can affect DHEA-S?
It may be higher with: DHEA supplementation, Regular exercise, Caloric restriction, Stress reduction, Adequate sleep. It may be lower with: Aging (primary factor — 2-3% decline per year after 25), Chronic stress (adrenal fatigue theory), Corticosteroid use, Chronic illness, Opioid medications.