Immunoglobulin E

immunohematologyImmunity & InflammationBlood

Immunoglobulin E (IgE) is an antibody class involved in the body's response to allergens — pollen, dust, certain foods — and parasitic infections. Most people have low total IgE in circulation; sensitized individuals can have markedly higher levels.

Why it matters: Total IgE is a screening signal for atopic tendency — the underlying predisposition to allergic reactions. Higher-than-typical levels are common in people with hay fever, asthma, eczema, or food sensitivities.

Symptoms of Low Immunoglobulin E
Typically without noticeable symptoms
Symptoms of High Immunoglobulin E
Sneezing or runny nose
Itchy or watery eyes
Hives or rash
Wheezing or asthma symptoms
Eczema flare-ups
What Moves It

May increase with:

Allergies
Parasitic infections
Atopic dermatitis

May decrease with:

Immunosuppressive therapy
CVID
Associated Conditions
Allergic rhinitisUrticariaEczema
Related Markers
EosinophilsIgGIgA
Common questions

What is Immunoglobulin E?

Immunoglobulin E (IgE) is an antibody class involved in the body's response to allergens — pollen, dust, certain foods — and parasitic infections. Most people have low total IgE in circulation; sensitized individuals can have markedly higher levels.

What might a high or low Immunoglobulin E mean?

Total IgE is a screening signal for atopic tendency — the underlying predisposition to allergic reactions. Higher-than-typical levels are common in people with hay fever, asthma, eczema, or food sensitivities.

What can affect Immunoglobulin E?

It may be higher with: Allergies, Parasitic infections, Atopic dermatitis. It may be lower with: Immunosuppressive therapy, CVID.

More in immunohematology
ABO Blood GroupRh(D) Blood GroupRheumatoid Factor

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