Bilirubin (Indirect)
Indirect (unconjugated) bilirubin is the form of bilirubin circulating in the blood before the liver has processed it. It is bound to albumin for transport and is not water-soluble. This is the form that accumulates in Gilbert syndrome and hemolytic conditions.
Why it matters: Elevated indirect bilirubin usually points to either increased red blood cell breakdown (hemolysis) or impaired liver uptake/conjugation. Gilbert syndrome, the most common cause, is benign and affects up to 10% of the population. Less commonly, elevated indirect bilirubin can indicate hemolytic anemia or ineffective red blood cell production.
May increase with:
May decrease with:
What is Bilirubin (Indirect)?
Indirect (unconjugated) bilirubin is the form of bilirubin circulating in the blood before the liver has processed it. It is bound to albumin for transport and is not water-soluble. This is the form that accumulates in Gilbert syndrome and hemolytic conditions.
What might a high or low Bilirubin (Indirect) mean?
Elevated indirect bilirubin usually points to either increased red blood cell breakdown (hemolysis) or impaired liver uptake/conjugation. Gilbert syndrome, the most common cause, is benign and affects up to 10% of the population. Less commonly, elevated indirect bilirubin can indicate hemolytic anemia or ineffective red blood cell production.
What is the typical reference range for Bilirubin (Indirect)?
The general-population reference range shown here is < 19 umol/L. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.
What can affect Bilirubin (Indirect)?
It may be higher with: Hemolytic anemia, Gilberts syndrome, Ineffective erythropoiesis. It may be lower with: Rare.
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