Anti-Thyroglobulin
Anti-thyroglobulin antibodies (Anti-TG) target thyroglobulin, the protein scaffold the thyroid uses to synthesize and store thyroid hormones. Like Anti-TPO, they are associated with autoimmune thyroid disease but are less specific and less commonly elevated than Anti-TPO.
Why it matters: Anti-TG is positive in about 60% of Hashimoto's thyroiditis and is sometimes the only antibody present (10-15% of autoimmune thyroid cases are Anti-TG positive but Anti-TPO negative). Anti-TG antibodies are also important in thyroid cancer monitoring because they interfere with thyroglobulin measurements used for surveillance.
May increase with:
May decrease with:
What is Anti-Thyroglobulin?
Anti-thyroglobulin antibodies (Anti-TG) target thyroglobulin, the protein scaffold the thyroid uses to synthesize and store thyroid hormones. Like Anti-TPO, they are associated with autoimmune thyroid disease but are less specific and less commonly elevated than Anti-TPO.
What might a high or low Anti-Thyroglobulin mean?
Anti-TG is positive in about 60% of Hashimoto's thyroiditis and is sometimes the only antibody present (10-15% of autoimmune thyroid cases are Anti-TG positive but Anti-TPO negative). Anti-TG antibodies are also important in thyroid cancer monitoring because they interfere with thyroglobulin measurements used for surveillance.
What is the typical reference range for Anti-Thyroglobulin?
The general-population reference range shown here is < 4 IU/mL. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.
What can affect Anti-Thyroglobulin?
It may be higher with: Hashimoto's thyroiditis, Graves' disease, Thyroid cancer (some cases), Other autoimmune conditions, Family history of thyroid autoimmunity. It may be lower with: Immunosuppressive therapy, Selenium supplementation, Thyroid tissue destruction (late stage).
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