Basophils

What is Basophils?

Basophils are the rarest white blood cells (less than 1% of WBCs), containing histamine and heparin granules. They play a role in allergic reactions, parasitic defense, and inflammatory modulation. Basophils are related to tissue mast cells and contribute to immediate hypersensitivity (type I allergic) responses.

What might a high or low Basophils mean?

Basophilia (elevated basophils) is uncommon and clinically significant when present. It can indicate myeloproliferative neoplasms (CML, polycythemia vera), allergic conditions, or chronic inflammation. Basophilia in the context of other CBC abnormalities warrants evaluation for myeloproliferative disorders.

What is the typical reference range for Basophils?

The general-population reference range shown here is 0 – 0.2 10x9/L. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.

What can affect Basophils?

It may be higher with: Chronic myeloid leukemia (CML), Polycythemia vera, Myelofibrosis, Allergic conditions, Hypothyroidism, Chronic inflammatory bowel disease, Estrogen therapy. It may be lower with: Acute allergic reactions (degranulation), Corticosteroids, Hyperthyroidism, Acute stress, Acute infection.