Lymphocytes

What is Lymphocytes?

Lymphocytes are white blood cells central to adaptive immunity. They include T cells (cell-mediated immunity, killing virus-infected cells), B cells (producing antibodies), and Natural Killer cells (innate antitumor defense). Lymphocytes are the second most abundant WBC type (20-40%) and have long lifespans — memory cells persist for decades.

What might a high or low Lymphocytes mean?

Elevated lymphocytes (lymphocytosis) typically indicate viral infection or, chronically, lymphoproliferative disorders (CLL). Low lymphocytes (lymphopenia) indicate immune suppression and are used in PhenoAge calculation — chronic lymphopenia is associated with accelerated biological aging and increased mortality risk.

What is the typical reference range for Lymphocytes?

The general-population reference range shown here is 1 – 4 10x9/L. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.

What can affect Lymphocytes?

It may be higher with: Viral infections (EBV, CMV, hepatitis, HIV early), Chronic lymphocytic leukemia (CLL), Pertussis (whooping cough), Tuberculosis, Autoimmune conditions, Stress (acute — redistribution from tissues). It may be lower with: HIV/AIDS, Corticosteroid therapy, Chemotherapy and radiation, Severe acute illness and sepsis, Malnutrition, Autoimmune conditions (lupus), Aging (immunosenescence), Chronic stress (cortisol suppression).