Neutrophils

What is Neutrophils?

Neutrophils are the most abundant white blood cells (40-70% of WBCs), serving as the first line of defense against bacterial and fungal infections. They migrate rapidly to infection sites, engulf pathogens through phagocytosis, and release antimicrobial enzymes. Neutrophils have a very short lifespan of 5-90 hours.

What might a high or low Neutrophils mean?

Raised neutrophils are associated with acute bacterial infection, inflammation, or a stress response. Low neutrophils are associated with greater susceptibility to bacterial and fungal infection, and a very low count is taken seriously clinically.

What is the typical reference range for Neutrophils?

The general-population reference range shown here is 2 – 7.5 10x9/L. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.

What can affect Neutrophils?

It may be higher with: Bacterial infection (primary driver), Acute inflammation, Physical or emotional stress (cortisol effect), Smoking, Corticosteroid medications, Post-exercise (transient), Tissue necrosis (burns, MI). It may be lower with: Viral infections (often reduce neutrophils), Chemotherapy and radiation, Autoimmune neutropenia, Medications (carbimazole, clozapine, methotrexate), B12/folate deficiency, Aplastic anemia, Severe sepsis (consumption).