HOMA-IR
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a calculated index that estimates insulin resistance from fasting glucose and fasting insulin: HOMA-IR = (Fasting Insulin in mU/L x Fasting Glucose in mmol/L) / 22.5. It models the feedback loop between the pancreas and liver in the fasting state.
Why it matters: HOMA-IR estimates insulin resistance, which is closely associated with metabolic syndrome and often precedes type 2 diabetes by years. Tracking it over time can reveal a metabolic trend before fasting glucose or HbA1c shift.
May increase with:
May decrease with:
What is HOMA-IR?
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a calculated index that estimates insulin resistance from fasting glucose and fasting insulin: HOMA-IR = (Fasting Insulin in mU/L x Fasting Glucose in mmol/L) / 22.5. It models the feedback loop between the pancreas and liver in the fasting state.
What might a high or low HOMA-IR mean?
HOMA-IR estimates insulin resistance, which is closely associated with metabolic syndrome and often precedes type 2 diabetes by years. Tracking it over time can reveal a metabolic trend before fasting glucose or HbA1c shift.
What is the typical reference range for HOMA-IR?
The general-population reference range shown here is < 2.5 -. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.
What can affect HOMA-IR?
It may be higher with: Visceral obesity, High carbohydrate diet, Physical inactivity, Poor sleep quality, Chronic stress, Excess fructose/sugar intake, Inflammation, Genetic predisposition. It may be lower with: Weight loss (especially visceral fat), Low-carb diet, Regular exercise, Intermittent fasting, Adequate sleep (7-9 hours), Stress reduction, Berberine supplementation, Metformin.