MPV
Mean platelet volume (MPV) measures the average size of platelets in femtoliters. Larger platelets are younger, more metabolically active, and more prone to aggregation. MPV reflects bone marrow platelet production dynamics — rapid turnover produces larger platelets.
Why it matters: MPV helps distinguish the cause of abnormal platelet counts. High MPV with low platelets suggests peripheral destruction (immune thrombocytopenia) — the marrow is compensating with larger, younger platelets. Low MPV with low platelets suggests production failure (bone marrow suppression). High MPV is also independently associated with cardiovascular risk.
May increase with:
May decrease with:
What is MPV?
Mean platelet volume (MPV) measures the average size of platelets in femtoliters. Larger platelets are younger, more metabolically active, and more prone to aggregation. MPV reflects bone marrow platelet production dynamics — rapid turnover produces larger platelets.
What might a high or low MPV mean?
MPV helps distinguish the cause of abnormal platelet counts. High MPV with low platelets suggests peripheral destruction (immune thrombocytopenia) — the marrow is compensating with larger, younger platelets. Low MPV with low platelets suggests production failure (bone marrow suppression). High MPV is also independently associated with cardiovascular risk.
What is the typical reference range for MPV?
The general-population reference range shown here is 7.4 – 10.4 fL. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.
What can affect MPV?
It may be higher with: Immune thrombocytopenia (compensatory production), Myeloproliferative disorders, Sepsis, Diabetes, Hyperthyroidism, Smoking, Cardiovascular disease. It may be lower with: Bone marrow suppression (chemotherapy), Aplastic anemia, Iron deficiency (reactive small platelets), Inflammatory conditions (cytokines suppress MPV).