Platelets

What is Platelets?

Platelets (thrombocytes) are small cell fragments produced by megakaryocytes in the bone marrow. They are essential for hemostasis — forming the initial plug at sites of blood vessel injury and providing a surface for the coagulation cascade. Platelets also release growth factors that aid wound healing and modulate inflammation.

What might a high or low Platelets mean?

Low platelets (thrombocytopenia) are associated with greater bleeding risk — from easy bruising at moderate lows to more serious bleeding when very low. High platelets (thrombocytosis) can be associated with greater clotting risk. Reactive thrombocytosis from inflammation or iron deficiency is far more common than primary bone-marrow causes.

What is the typical reference range for Platelets?

The general-population reference range shown here is 150 – 400 10x9/L. Reference ranges describe the general population and are not a personal target — discuss your results with your physician.

What can affect Platelets?

It may be higher with: Iron deficiency (reactive thrombocytosis), Acute or chronic inflammation, Infection, Post-splenectomy, Essential thrombocythemia, Blood loss (compensatory), Malignancy, Recovery from chemotherapy (rebound). It may be lower with: Immune thrombocytopenia (ITP), Bone marrow suppression (chemo, radiation), Viral infections (EBV, HIV, hepatitis C), Liver cirrhosis (splenic sequestration), Medications (heparin, valproic acid), Alcohol excess, DIC (disseminated intravascular coagulation), B12/folate deficiency.