ApoB/ApoA1 Ratio
The ApoB/ApoA1 ratio compares the number of atherogenic particles (ApoB — one per LDL, VLDL, Lp(a)) to anti-atherogenic particles (ApoA1 — primary HDL protein). This single ratio captures the balance between cholesterol deposition in arteries and cholesterol removal from arteries.
Why it matters: The ApoB/ApoA1 ratio is one of the strongest predictors of myocardial infarction, outperforming traditional lipid ratios in the INTERHEART study across 52 countries. A high ratio means the balance tips toward atherosclerosis progression. It integrates both sides of lipid metabolism into one actionable number.
May increase with:
May decrease with:
What is ApoB/ApoA1 Ratio?
The ApoB/ApoA1 ratio compares the number of atherogenic particles (ApoB — one per LDL, VLDL, Lp(a)) to anti-atherogenic particles (ApoA1 — primary HDL protein). This single ratio captures the balance between cholesterol deposition in arteries and cholesterol removal from arteries.
What might a high or low ApoB/ApoA1 Ratio mean?
The ApoB/ApoA1 ratio is one of the strongest predictors of myocardial infarction, outperforming traditional lipid ratios in the INTERHEART study across 52 countries. A high ratio means the balance tips toward atherosclerosis progression. It integrates both sides of lipid metabolism into one actionable number.
What is the typical reference range for ApoB/ApoA1 Ratio?
The general-population reference range shown here is < 0.9 . Reference ranges describe the general population and are not a personal target — discuss your results with your physician.
What can affect ApoB/ApoA1 Ratio?
It may be higher with: Rising LDL particle count, Falling HDL particle count, Metabolic syndrome, Insulin resistance, Smoking, Sedentary lifestyle. It may be lower with: Statins, Exercise, Weight loss, Smoking cessation, Mediterranean diet, Omega-3 fatty acids.
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